SEARCH TERM: VDR
Gene Overview
The VDR (Vitamin D Receptor) gene encodes a protein critical for binding active vitamin D (1,25-dihydroxyvitamin D). Through this binding, VDR regulates a variety of metabolic pathways, including calcium absorption, bone health, immune function, and inflammation control. It also influences processes such as insulin-like growth factor signaling, estrogen pathways, and cell-cycle regulation. Variants in the VDR gene can affect how well your body responds to vitamin D, potentially impacting bone strength, metabolic health, and immunity.
VDR Bsm1 (G>A)
Impact Allele: A allele
Impact
A allele (negative)
- Bone Health:
- Associated with reduced bone mineral density (BMD) and higher risk of osteoporosis.
- Increased bone loss from the hip in postmenopausal women with low calcium intake.
- High caffeine intake (>300 mg/day) exacerbates osteoporosis risk in AA genotype carriers.
- Power:
- AA genotype is linked to potential power-related performance.
- Vitamin D:
- Impacts VDR gene expression, indirectly influencing systems reliant on vitamin D.
Next Steps:
- Consult your genomics specialist or doctor for tailored bone health strategies.
- Focus on adequate calcium and vitamin D intake.
- Limit caffeine consumption to reduce bone loss risk.