VDR Taq1 (T>C)
Impact Allele: C allele
Impact
C allele (negative)
- Bone Health:
- CC genotype linked to 7–10% lower bone density and higher bone loss rates in women, especially with high caffeine intake (>300 mg/day).
- CC carriers respond well to vitamin D supplementation.
- Vitamin D:
- Associated with lower calcidiol (vitamin D precursor) and calcitriol function.
- Impacts immune cell activity due to reduced vitamin D receptor availability.
- Power:
- CC genotype linked to better baseline strength, muscle torque, and strength training response.
Next Steps:
- Work with a healthcare provider to ensure optimal vitamin D supplementation.
- Incorporate strength training to leverage potential power performance benefits.
- Limit caffeine intake to prevent bone loss.
Summary
The VDR gene plays a critical role in multiple pathways, including bone health, vitamin D metabolism, and immune function. Variants in Bsm1, Fok1, and Taq1 may impact calcium absorption, BMD, immune regulation, and muscle performance. Tailored dietary, supplementation, and lifestyle strategies are recommended based on your genetic profile.