VDR Fok1 (T>C)
Impact Allele: T allele
Impact
T allele (negative)
- Bone Health:
- Reduced receptor sensitivity, leading to poor calcium absorption.
- Associated with increased bone turnover, lower BMD, osteoporosis, and osteopenia.
- Vitamin D:
- T allele reduces the effectiveness of vitamin D binding, potentially mimicking vitamin D deficiency symptoms.
- Immune Function:
- T allele linked to reduced immune response and increased cancer risk.
Next Steps:
- Consider regular vitamin D supplementation and monitor calcium levels.
- Engage in weight-bearing exercises to support bone health.
- Discuss immune support strategies with your doctor.