Gene Overview
The UGT2B (Uridine diphosphate-glucuronosyltransferase 2B) family includes enzymes that metabolize steroid hormones such as testosterone, dihydrotestosterone (DHT), and androsterone (ADT). These enzymes play a vital role in detoxification, facilitating the removal of steroid hormones and other endobiotic (body-produced) and xenobiotic (external) substances from the body through urine. Variants in these genes can impact hormone metabolism and detoxification efficiency, potentially leading to hormonal imbalances.
UGT2B15
Variant: T>G
Impact Allele: G allele
Impact:
- G allele (negative):
- Reduced UGT2B15 enzyme activity, leading to impaired detoxification of steroid hormones.
- Female-Specific Implications: Lower capacity to detoxify testosterone, which may require additional support for hormonal balance.
UGT2B17
Variant: INS/DEL
Impact Allele: DELETION
Impact:
- Deletion (negative):
- Complete loss of UGT2B17 enzyme activity, resulting in reduced ability to bind and remove steroid hormones.
- Female-Specific Implications: Decreased detoxification of testosterone and other steroid hormones, leading to hormonal dysregulation.
Next Steps:
- Consult your genomics specialist or doctor to assess hormone levels and evaluate the efficiency of your detoxification pathways.
- Adopt dietary and lifestyle modifications to support liver function and enhance detoxification, such as increasing intake of cruciferous vegetables, fiber, and foods rich in antioxidants.